FROM PEER-REVIEWED, RESPECTED JOURNALS (not shade-tree magazines).
Just a few of many articles published in medical and scientific journals which support Radical Detox as by far the most effective detox product in America. Many of these articles cited may be found at http://www.ncbi.nlm.nih.gov/pubmed/
Ethanol detoxification
  1. Involvement of UDP-glucuronosyltransferases UGT1A9 and UGT2B7 in ethanol glucuronidation, and interactions with common drugs of abuse. Al Saabi A, et al., Drug Metab Dispos. Vol. 41(3), 568-574 (2013).
  2. Clinical sensitivity and specificity of meconium fatty acid ethyl ester, ethyl glucuronide, and ethyl sulfate for detecting maternal drinking during pregnancy. Himes SK, et al. Clin Chem. Vol. 61(3), 523-532 (2015).
Cannabis detoxification
  1. Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids. Mazur, A., et al., in Drug Metabol. Disposition Vol. 37, 1496–1504 (2009).
  2. Conjugation of Synthetic Cannabis JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases. Chimalakonda, K.C., et al., in Drug Metabol. Disposition Vol. 39, 1967–1976 (2011).
  3. Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Stout, S.M. and Cimono, N.M., in Drug Metab. Review Vol. 46, 86-95 (2014).
  4. In Vitro Stability of Free and Glucuronidated Cannabinoids in Urine Following Controlled Smoked Cannabis. Desrosiers, N.A., et al, in Anal. Bioanal. Chem. Vol. 406, 785–792 (2014).
  5. Current Knowledge on Cannabinoids in Oral Fluids. Lee, D. and Huestis, M.A. in Drug Test Anal. Vol. 6, 88-111 (2014).
  6. Cannabinoid disposition in oral fluid after controlled smoked, vaporized, and oral cannabis administration. Swortwood MJ, et al. in Drug Test Anal. Vol. 9(6), 905-915 (2017)
  7. Cannabis Edibles: Blood and Oral Fluid Cannabinoid Pharmacokinetics and Evaluation of Oral Fluid Screening Devices for Predicting Δ(9)-Tetrahydrocannabinol in Blood and Oral Fluid following Cannabis Brownie Administration. Newmeyer, M.N., et al. Clinical Chemistry Vol.  63(3), 647-662 (2017)
  8. Pharmacokinetic Profile of Oral Cannabis in Humans: Blood and Oral Fluid Disposition and Relation to Pharmacodynamic Outcomes. Vandrey, R., et al. Journal of Analytical Toxicology Vol. 41(2), 83-99 (2017)
  9. Patient-Reported Symptom Relief Following Medical Cannabis Consumption. Stith, S.S., et al. Frontiers in Pharmacology Vol. 9 (2018) DOI: 10.3389/fphar.2018.00916
  10. Effectiveness of Raw, Natural Medical Cannabis Flower for Treating Insomnia under Naturalistic Conditions. Vigil, J., et al., Medicines Vol. 5 (3), 75 (2018) DOI: 10.3390/medicines5030075
Cannabis, synthetic
  1. Synthetic Cathinone and Cannabinoid Designer Drugs Pose a Major Risk for Public Health. Weinstein, A.M., et al., Frontiers in Psychiatry Vol. 8, 156 (2017)
  2. Marijuana Poisoning. Fitzgerald, K.T., Bronstein, A.C. and Newquist, K.L. in Top Companion Animal Medicine Vol. 28(1), 8-12 (2013).
Tobacco and nicotine detoxification
  1. Detection of tobacco smoke emanating from human skin surface of smokers employing passive flux sampler - GCMS system. Sekine, Y. et al., J Chromatogr B Analyt Technol Biomed Life Sci. Vol.1092, 394-401, (2018).
  2. Comparison of the Conventional and Electroenhanced Direct-Immersion Solid-Phase Microextraction for Sampling of Nicotine in Biological Fluids of the Human Body. Abdolhosseini, S. et al., in Molecules Vol. 32, 1171 (2018).
  3. Importance of UDP-glucuronosyltransferases 2A2 and 2A3 in tobacco carcinogen metabolism. Bushey, R. T. et al., in Drug Metabol. Disposition Vol. 41, 170-9 (2013).
  4. Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues. Zheng, G., et al., Drug Metabol. Disposition Vol. 30, 397-403 (2002).
  5. Interception of benzo[a]pyrene-7,8-dione by UDP glucuronosyltransferases (UGTs) in human lung cells. Zhang, L., et al., in Chem. Res. Toxicol. Vol. 26, 1570-1578 (2013).​
Opioid detoxification
  1. Identification of New Opioid Metabolites in Human Urine by Capillary Electrophoresis-multiple-stage Ion-trap Spectrometry. Baldacci, A. et al., in  J. Chromatogr. A Vol. 1051, 273-82 (2004).
  2. Changing patterns in opioid addiction: characterizing users of oxycodone and other opioids. Sproule, B. in Can. Fam.Physician Vol. 55, 68-9.e1-5 (2009).
Ibuprofen detoxification
  1. Production of Ibuprofen Acyl Glucosides by Human UGT2B7. Buchheit, D., et al., in Amer. Soc. Phamacol. Exp. Therapeut. Vol. 39, 2174-81 (2011).
  2. Glucuronidation of Nonsteroidal Anti-Inflammatory Drugs: Idetifying the Enzymes Responsible in Human Liver Microsomes. Kuehl, G.E., et al., in Drug Metabol. Disposition Vol. 33, 1027-1035 (2005).
  3. Effects of Dietary Anticarcinogens and Nonsteroidal Anti-inflammatory Drugs on Rat Gastrointestinal UDP-Glucuronosyltransferases. Van Der Logt, E.M.J., et al., Anticancer Res. Vol. 24, 843-850 (2004).
Paracetamol detoxification
  1. Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronosyltransferases. Bock, K.W., et al., in Biochem. Pharmacol. Vol. 45, 1809-1814 (1993).
    Glucuronidation in Humans. Pharmacogenetic and developmental aspects. De Wildt, S.N., et al., in Clin. Pharmokinet. Vol. 36, 439-52 (1999).
  2. Restricting paracetamol in the United Kingdom to reduce poisoning: a systematic review. Morgan, O. and Majeed, A. in J. Public Health Vol. 27, 12-18 (2004).
  3. Recent Updates on Acetaminophen Hepatotoxicity: The Role of Nrf2 in Hepatoprotection. Gum, S.I. and Cho, M.K. in Toxicol. Res. Vol. 29, 165-172 (2013).
Withdrawal
  1. 5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal. Ohmura, Y., et al., in J. Pharmacol. Sci. Vol. 117, 121-4 (2011).
  2. L-Theanine Attenuates Abstinence Signs in Methamphetamine-Dependent Rhesus Monkeys and Elicits Anxiolytic-Like Activity in Mice. Wise, L.E., et al., in Pharmacol. Biochem. Behav. Vol. 103, 245-52 (2012).
  3. Neurotransmitter-precursor-supplement intervention for detoxified heroin addicts. Chen D., et al., in J. Huazhong Univ. Sci. Technolog. Med. Sci. Vol. 32, 422-427 (2012).
  4. The use of a food supplementation with D-phenylalanine, L-glutamine and L-5-hydroxytryptophan in the alleviation of alcohol withdrawal symptoms. Jukić T., et al., in Collegium Antropologicum Vol. 35, 1225-1230 (2011).
  5. Zinc deficiency and corticosteroids in the pathogenesis of alcoholic brain dysfunction – a review. Menzano, E. and Carlen, P. L., in Alcohol Clinical Experimental Research Vol. 18, 895-901 (1994).
Heroin and Morphine detoxification and toxicity
  1. High Levels of Morphine-6-glucuronide in Street Heroin Addicts. Antonilli, J., et al., in Psychopharmacology (Berlin) Vol. 170, 200-4 (2003).
  2. Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies. Chou, N., et al., in J. Pharmacol. Exp. Ther. Vol. 349, 126-137 (2014).
  3. Morphine metabolism, transport and brain disposition. De Gregori, S. et al., in Metab. Brain Dis. Vol. 27, 1–5 (2012).
  4. Increases in Drug and Opioid Overdose Deaths--United States, 2000-2014. Rudd, R.A., et al., Morbidity and Mortality Weekly Report (MMWR) Vol. 64(50-51), 1378-82. (2016).
Methamphetamine detoxification and toxicity
  1. Urinary excretion of the Main Metabolites of Methamphetamine, Including p-Hydroxymethamphetamine-sulfate and p-Hydroxymethamphetamine-glucuronide in Humans and Rats. Shima, N.,et al., in Xenobiotica, Vol. 36, 259-67 (2006).
  2. Investigation on the Enantioselectivity of the Sulfation of the Methylenedioxymethamphetamine Metabolites 3,4 Dihydroxymethamphetamine and 4-Hydroxy-3-Methoxymethamphetamine using the Substrate-Depletion Approach. Schwaninger, A.E. et al.,in Drug Metabol. Disposition Vol. 39, 1998–2002 (2011).
  3. Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia. Matsumoto, R.R.,  et al. in Pharmacol Ther. Vol.  144(1),  28–40  (2014).
  4. In vivo evidence for long-term CNS toxicity, associated with chronic binge use of methamphetamine Chung, Y.A., et al., in Drug Alcohol Depend. Vol. 111,  155-60 (2010).
Ecstasy detoxification
  1. Toxicokinetics and analytical toxicology of amphetamine-derived designer drugs ('Ecstasy'). Mauer, HH., et al., in Toxicology Letters, Vol. 112-113, 133-42 (2000).
  2. The role of human UDP-glucuronyltransferases on the formation of the ecstasy phase II metabolites R- and S-3-m... 4-O-glucuronides. Schwaninger, A.E. et al., in Drug Metabol. Disposition Vol. 37, 2212-2220 (2009).
Zinc
  1. Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges. Al-Nakib, W., et al., in J. Antimicrobial Chemotherapy, Vol. 20, 893-901 (1987).
  2. Oral zinc for the common cold. Das, R. R. and Singh, M. in Journal of the American Medical Society, Vol. 311, 1440-1441 (2014).
  3. Zinc for the common cold. Singh, M. and Das, R. R., in Cochrane Database Systematic Review, Vol. 16, CD001364 (2011).