Just a few of many articles published in serious medical and scientific journals which support Radical Detox as by far the most effective detox product in America.  Many of these articles cited may be found at http://www.ncbi.nlm.nih.gov/pubmed/

Cannabis detoxification
  1. Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids. Mazur, A., et al., in Drug Metabol. Disposition Vol. 37, 1496–1504 (2009).
  2. Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyl-transferases. Chimalakonda, K.C., et al., in Drug Metabol. Disposition Vol. 39, 1967–1976 (2011).
  3. Exogenous cannabis as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Stout, S.M. and Cimono, N.M., in Drug Metab. Review Vol. 46, 86-95 (2014).
Opioid detoxification
  1. Identification of New Opioid Metabolites in Human Urine by Capillary Electrophoresis-multiple-stage Ion-trap Spectrometry. Baldacci, A. et al., in J. Chromatogr. A Vol. 1051, 273-82 (2004).
  2. Changing patterns in opioid addiction: characterizing users of oxycodone and other opioids. Sproule, B., et al., in Can. Fam. Physician Vol. 55, 68-9.e1-5 (2009).
Alcohol detoxification
  1. Involvement of UDP-glucuronosyltransferases UGT1A9 and UGT2B7 in ethanol glucuronidation, and interactions with common drugs of abuse. Al Saabi A, et al., Drug Metab Dispos. Vol. 41(3), 568-574 (2013).
  2. Clinical sensitivity and specificity of meconium fatty acid ethyl ester, ethyl glucuronide, and ethyl sulfate for detecting maternal drinking during pregnancy. Himes SK, et al. Clin Chem. Vol. 61(3), 523-5
 (Tobacco) detoxification
  1. Importance of UDP-glucuronosyltransferases 2A2 and 2A3 in tobacco carcinogen metabolism. Bushey, R. T. et al., in Drug Metabol. Disposition Vol. 41, 170-9 (2013).
  2. Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues. Zheng, G., et al., Drug Metabol. Disposition Vol. 30, 397-403 (2002).
  3. Interception of benzo[a]pyrene-7,8-dione by UDP glucuronosyltransferases (UGTs) in human lung cells. Zhang, L., et al., in Chem. Res. Toxicol. Vol. 26, 1570-1578 (2013).
 Ibuprofen detoxification 
  1. Production of Ibuprofen Acyl Glucosides by Human UGT2B7. Buchheit, D., et al., in Amer. Soc. Phamacol. Exp. Therapeut. Vol. 39, 2174-81 (2011).
  2. Glucuronidation of Nonsteroidal Anti-Inflammatory Drugs: Idetifying the Enzymes Responsible in Human Liver Microsomes. Kuehl, G.E., et al., in Drug Metabol. Disposition Vol. 33, 1027-1035 (2005).
  3. Effects of Dietary Anticarcinogens and Nonsteroidal Anti-inflammatory Drugs on Rat Gastrointestinal UDP-Glucuronosyltransferases. Van Der Logt, E.M.J., et al., Anticancer Res. Vol. 24, 843-850 (2004).
Paracetamol detoxification
  1. Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronosyltransferases. Bock, K.W., et al., in Biochem. Pharmacol. Vol. 45,1809-1814 (1993).
  2. Glucuronidation in Humans. Pharmacogenetic and developmental aspects. De Wildt, S.N., et al., in Clin. Pharmokinet. Vol. 36, 439-52 (1999).
  3. Restricting paracetamol in the United Kingdom to reduce poisoning: a systematic review. Morgan, O. and Majeed, A. in J. Public Health Vol. 27, 12-18 (2004).
  4. Recent Updates on Acetaminophen Hepatotoxicity: The Role of Nrf2 in Hepatoprotection. Gum, S.I. and Cho, M.K. in Toxicol. Res. Vol. 29, 165-172 (2013).
 Withdrawal
  1. 5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal. Ohmura, Y., et al., in J. Pharmacol. Sci. Vol. 117, 121-4 (2011).
  2. L-Theanine Attenuates Abstinence Signs in Methamphetamine-Dependent Rhesus Monkeys and Elicits Anxiolytic-Like Activity in Mice. Wise, L.E., et al., in Pharmacol. Biochem. Behav. Vol. 103, 245-52 (2012).
  3. Neurotransmitter-precursor-supplement intervention for detoxified heroin addicts.Chen D., et al., in J. Huazhong Univ. Sci. Technolog. Med. Sci. Vol. 32, 422-427 (2012).
  4. The use of a food supplementation with D-phenylalanine, L-glutamine and L-5-hydroxytryptophan in the alleviation of alcohol withdrawal symptoms. Jukić T., et al., in Collegium Antropologicum Vol. 35, 1225-1230 (2011).
  5. Zinc deficiency and corticosteroids in the pathogenesis of alcoholic brain dysfunction – a review.  Menzano, E. and Carlen, P. L., in Alcohol Clinical Experimental Research Vol. 18, 895-901 (1994).
 Heroin and Morphine detoxification
  1. High Levels of Morphine-6-glucuronide in Street Heroin Addicts. Antonilli, J., et al., in Psychopharmacology (Berlin) Vol. 170, 200-4 (2003).
  2. Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies. Chou, N., et al., in J. Pharmacol. Exp. Ther. Vol. 349, 126-137 (2014).
  3. Morphine metabolism, transport and brain disposition. De Gregori, S. et al., in Metab. Brain Dis. Vol. 27, 1–5 (2012).
  Methamphetamine detoxification
  1. Urinary excretion of the Main Metabolites of Methamphetamine, Including p-Hydroxymethamphetamine-sulfate and p-Hydroxymethamphetamine-glucuronide in Humans and Rats. Shima, N.,et al., in Xenobiotica, Vol. 36, 259-67 (2006).
  2. Investigation on the Enantioselectivity of the Sulfation of the Methylenedioxymethamphetamine Metabolites 3,4 Dihydroxymethamphetamine and 4-Hydroxy-3-Methamphetamine using the Substrate-Depletion Approach.Schwaninger, A.E. et al., in Drug Metabol. Disposition Vol. 39, 1998–2002 (2011).
 Ecstasy detoxification
  1. Toxicokinetics and analytical toxicology of methamphetamine-derived designer drugs ('Ecstasy').  Mauer, HH., et al., in Toxicology Letters, Vol. 112-113, 133-42 (2000).
  2. The role of human UDP-glucuronyltransferases on the formation of the ecstasy phase II metabolites R- and S-3-methamphetamine 4-O-glucuronides. Schwaninger, A.E. et al., in Drug Metabol. Disposition Vol. 37, 2212-2220 (2009).
 Zinc
  1. Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges. Al-Nakib, W., et al., in J. Antimicrobial Chemotherapy, Vol. 20, 893-901 (1987).
  2. Oral zinc for the common cold. Das, R. R. and Singh, M. in Journal of the American Medical Society, Vol. 311, 1440-1441 (2014).
  3. Zinc for the common cold. Singh, M. and Das, R. R., in Cochrane Database Systematic Review, Vol. 16, CD001364 (2011).
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